Dr. Anne Grosse-Wilde
Fähigkeiten und Kenntnisse
Werdegang
Berufserfahrung von Anne Grosse-Wilde
- Bis heute 8 Jahre und 11 Monate, seit Sep. 2016
Manager
Seagen
Biomarker lead for various solid tumor programs in clinical trials for solid tumor indications for various targeted therapeutics, including antibody drug conjugate (ADCs), combinations of ADCs with IO agents, and small molecule programs
- 10 Monate, Sep. 2015 - Juni 2016
Senior Research Scientist
Nortis, Inc
• Led research project to generate a novel microfluidics-based vascularized “breast cancer-on-chip” model • Protocol and tool development for quantitation of tumor growth in “cancer-on chip” model • Established anti-cancer drug screening assay in vascularized breast cancer-on-chip model • Augmented experimental capacity by engaging CRO in time-critical project
- 7 Jahre und 6 Monate, Jan. 2008 - Juni 2015
Research Scientist
Institute for Systems Biology
• Lead cross-functional team of bench scientist and computational biologists for analysis of complex in vitro and in vivo data, biomarker expression, validation using clinical data, and pathway analysis • Identification of biomarker signatures for individual breast cancer stem cells and functional validation in vitro and in primary tumors • Guided interns and research technicians
- 4 Jahre und 9 Monate, Mai 2003 - Jan. 2008
Postdoctoral Researcher
Fred Hutchinson Cancer Research Center
• Investigated physiological role and cellular antitumorigenic mechanisms of the immune effector TRAIL-R in vitro and in vivo • Examined role of diverse tumor suppressor proteins for sensitivity towards chemotherapy • Identified with TRAIL-R the first in vivo confirmed metastasis suppressor protein in mice
- 5 Jahre, Jan. 1998 - Dez. 2002
PhD student
DKFZ - Deutsches Krebsforschungszentrum
• Analyzed ligand/receptor-mediated apoptosis signaling pathways in immune cells and tumor cells • Identification and validation of the first murine TRAIL-receptor (TRAIL-R) in mice • Generated and tested protein-based agonistic and antagonistic tools and antibodies • Generated conditional mTRAIL-R knockout mice • Guided interns and research technicians
Ausbildung von Anne Grosse-Wilde
- 4 Jahre und 1 Monat, Jan. 1998 - Jan. 2002
Immunogenetics and Cancer
Bayerische Julius-Maximilians Universität Würzburg
- 12 Jahre und 11 Monate, Sep. 1994 - Juli 2007
Biology
Bayerische Julius-Maximilians Universität Würzburg
Cell and and Developmental Biology, Genetics, Biochemistry
- 2 Jahre, Okt. 1992 - Sep. 1994
Biology
Friedrich Alexander Universität Erlangen
Zoology, Botany, Physics, Chemistry
Sprachen
Englisch
Fließend
Spanisch
Grundlagen
Deutsch
Muttersprache
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