Dr. Björn Steinmann

• Heading a screening automation laboratory for high-throughput expression of large antibody libraries in mammalian cells for lead optimization. • Managing a state-of-the-art high-throughput laboratory automation system. Developing machine method programming and machine teaching. • Working in project teams for the development of therapeutic antibody leads in immunology, inflammation, and immuno-oncology.

• Heading a Molecular Biology laboratory focused on generating large positional and recombinatorial antibody libraries for lead optimization. • Developing monospecific antibodies and multispecific antibody-like formats, leveraging high-throughput and lab automation for efficient processing of both standard and large-scale cloning requests. • Working in project teams optimizing therapeutic antibody leads. • HSE Occupational Health and Safety Consultant for about 200 colleagues.

• Heading a phage panning laboratory discovering human antibody leads for early discovery pipeline. • Project lead external VHH antibody discovery. • Coordinating feasibility studies on innovative technologies and novel antibody formats. • Laser safety officer.

• Leading projects in yeast display technologies and external VHH antibody discovery. • Coordinating external “bispecifics activities” and assisting with FTO analysis. • Department representative in highly divers research teams “Core Team Cardio Vascular” and “Early Research - Acute Organ Disorder” giving pipeline project updates, evaluating and presenting new pipeline project proposals. • Laser safety officer.

• Developing and implementing yeast display systems for antibody lead discovery and optimization. • Implementing and optimizing flow cytometry and cell sorting technologies. • Coordinating an external cooperation on yeast cell lines. • Laser Safety Officer.

• Developing and implementing yeast display systems for antibody lead discovery and optimization. • Implementing and optimizing flow cytometry and cell sorting technologies (FACS). • Designing and assembling of yeast display libraries by modular Golden Gate cloning. • Coordinating an external cooperation on yeast cell lines.

• Breeding insects. • Producing biological crop protection products.

• Breeding insects. • Conducting experiments in the field of biological plant protection.

• Design and cloning of naïve and immune VHH single-domain phage and yeast display libraries • Screening VHH yeast libraries (MACS and FACS) • Collaborations with companies and institutes • Performing immunizations of sharks for the generation of immune VNAR single-domain libraries

Biochemistry, Animal Physiology, Cell- and Developmental Biology • Engineering of an in vivo system for the intracellular immobilization of active enzymes on protein particles (particle display)