Dr. Boris Krichel

My EU-funded project, called TopAMPK, brings together structural mass spectrometry and medical research. Until July 2024, I will be visiting Prof. Ying Ge at the University of Wisconsin-Madison to characterize the AMPK protein complex directly from donor heart tissue. The goal is to link certain forms of the AMPK complex to cardiovascular diseases in order to treat them in the future by precision medicine.

"Dynamics of viral structures - Uetrecht Group" -Manage lab and team @ Uni Siegen -Establish TopDown proteomics workflows for endogenous viral proteins -Native TopDown mass spectrometry of antibodies and protein complexes -Supervise graduate students in lab project and thesis writing -Establish laser lab and modify mass spectrometers for hydroxyl labelling and UV dissociation

• Research top-down MS of coronaviral nsp-RNA complexes, native MS of small molecule inhibitor binding to viral enzymes • Plan and implement gene technology approvals for group-wide S1 and S2 research projects • Supervise PhD, Master and Bachelor students • Set up protein production and mass spectrometry labs for Q-ToF, Q-Exactive UHMR and timsToF • Repair and maintain LC and MS systems and communicate with MS vendor companies • Coordinate sample preparation and operate DESY synchrotron beamtime experiments

-Mass spectrometry and structural biology of coronaviral proteins -RNA-protein binding -Established MS and Biochemistry research lab -PhD representative