Dr. Christoph Hirche

• Research on inflammatory signatures in Hematopoietic Stem Cells and their role both during homeostasis as well as inflammatory stress / ageing • Established in vivo viral infection models to study HSC biology in close collaboration with Twincore - Center for Clinical and Experimental Infection Research • Gained in-depth experience in blood and cancer biology, cell sorting, single-cell assays (transplants, quantitative RT-PCR) and flow cytometry

• Research on the impact of systemic chronic virus infections (i.e. Cytomegalovirus, CMV) on phenotype and function of Long-Term Hematopoietic Stem Cells • Established state-of the art HSC-methodologies and animal transplant models in close collaboration with the German Cancer Research Center, the Helmholtz Center for Infection Research and the ReBirth Cluster of Excellence of Hannover Medical School • Ph.D. thesis completed with overall grade „Summa Cum Laude“

• Establishing state of the art Hematopoietic Stem Cell methodologies on site

• Research to establish a Streptococcus suis-specific ELISA for human serum samples • Gained experience in protein purification, enzyme-linked immunosorbent assays and mass spectrometry

• Research on „Protein Misfoldig Cyclic Amplification“ (PMCA), a sensitive detection method for prion proteins in various tissues • Gained experience in prion protein biology, western blotting and laboratory work under S3+ conditions

• Research as part of the „Cambridge Neuroscience Network“ on motoneuronal development in the model organism Drosophila Melanogaster • Gained experience in high-resolution fluorescent microscopy, optogenetic motoneuron assays and fly genetics

"Impact of Virus Infections on Long-Term Hematopoietic Stem Cells" ;

Summer School Student ; Cambridge Neuroscience Network / Department of Zoology

Department of Veterinary Anatomy / Department of Microbiology

Language studies at the "Institut d'Etudes Françaises pour Etudiants Etrangers" (IEFEE)

5.-8. grade were completed at the German School Seoul (South Korea)