Dr. Claus Hultschig

Key responsibilities: *Analyzing next generation sequencing data. *Determination of mutations indicative for Malignant Hyperthermia. *Establishing an analysis pipeline for the identification of mutations in patient sample ­data. * Experimental design Major achievements: * Identification a set of new point mutations indicative for Malignat Hyperthermia. * Establishing end to end analysis pipelines for the determination of indication specific SNP starting with NGS fastq files.

Key responsibilities: * Analyzing next generation sequencing data (RNA-Seq). * Data analysis using R, Linux programs and command line tools on the sciCORE High Performance Computing Cluster. * Development of Python programs for data extraction, conversion and analysis. * Developing new bio-informatic methods Major achievements: * Identification of methods for estimation of RNA degradation using RNA-Seq data. * Programming new bioinformatic routines for estimating RNA degradation.

Design of laboratory automation procedures. Identification and evaluation of new technologies. Data analysis.

Identifying high throughput technology platforms producing relevant data for consortium-wide high-impact publications In close collaboration with the lead scientist of each technology platform, defining the acceptable numeric ranges and formats of data to be uploaded to a database system Translating scientific needs into specifications of data processing routines Supporting scientists in the use of the developed database Reporting the progress of the database implementation to the European community

Aufgaben: * Verbesserung, Organisation und Betrieb des Microarray Print Laboratoriums. * Ausarbeitung von Standard Operating Procedures. * Entwurf, Überwachung und Teilnahme an einer Evaluierungsstudie über die Eignung des NovaChips für diagnostische Fragestellungen. Haupterfolge: * Optimierung der Protokolle zur Microarray Herstellung und Verwendung. Gewährleistung des fristgerechten und erfolgreichen Abschlusses der NovaChip Evaluierung.

Peptid Arraytechnologie, Phagedisplay, Biacore, molekulare Wechselwirkungen,

Chemie Hauptstudium an der Universität Konstanz mit Diplomarbeit in der Arbeitgruppe für bioorganische Chemie, Fakultät für Biologie, Universität Konstanz unter der Anleitung von Prof. Dr. S. Ghisla.Abschluss: Diplom-Chemiker.

Hauptstudium der Umweltwissenschaften

Chemie Grundstudium