Dr. Detlef Schumann

Chairman of the Board CEO, CFO

* R&D Management of internal and external research projects in orthopaedics/trauma & Drug Delivery - set up of worldwide collaborations with academical and clinical partners - design of in-vitro and in-vivo studies for biomedical applications - Discussions with clinicians to find biomaterial/device solutions for their clinical needs - Contact partner for academics and clinicians in governmental programs (e.g.BMM) - R&D contact for medical device industry in the orthopaedic and trauma field

Alexander von Humboldt Scholar Postdoc at MIT and Harvard Department of biomedical engineering (MIT) Harvard Medical - Center for genetics (Harvard) Investigated the influence of mechanobiological load on OA explants in a simulated in vivo environment to investigate changes in catabolic or anabolic pathways on the gene and protein level. - Novel knowledge could help in innovative drug design for the treatment of degenerative diseases of the musculoskeletal system (e.g. Osteoarthritis)

Postdoc Headed large animal trial for lumbar spine fusion. Bone Tissue engineering. Application of modern techniques in regenerative medicine (Rapid prototyping of spinal cages, innovative biomaterial design, growth factor delivery strategies, stem cell culture and application) Bioreactor design for osteochondral repair. Stem cell applications. Large animal operation and project management. Supervision of PhD and master students.

R&D Management and Center Management Regenerative Therapies (R&D): Human Stem cell applications.Cartilage and Bone regeneration using innovative biomaterials (custom made) plus drug delivery strategies and human bone marrow derived stem cells. - Management of architectural, financial and inventory aspects - Responsible for business affairs - Did business plan writing for start up company - Organised transfer of six research units from different departments into the center - Public relation management

Research for PhD thesis. Bioreactor (3x) design to apply mechanobiological load (direct compression, hydrostatic and ultrasound) on human bone marrow derived stem cells for cartilage regeneration strategies. Design of intravital microscopy techniques to investigate Angiogenisis in meniscal, chondrocytes or stem cell loaded biomaterials during their chondrogenic differentiation in vivo.- Instructed and supervised the lab personal and medical undergraduate/graduate students studying for a doctorate.

- Managed GMP and GLP affairs in the Quality Control - Manufactured cytostatics and other drugs under sterile conditions - Developed and validated new analytical methods - Did all kinds of modern analytical methods (HPLC, GC, IR, UV-VIS, TLC etc.) - Project Management

- Manufactured drugs - Supervised and performed drug control and storage - Advised customers - Managed economic affairs

- Influence of mechanobiological loading on healthy and pathological modified (Osteoarthritis) human cartilage tissue in a simulated in vivo situation.. - Novel knowledge could help in innovative drug design for the treatment of degenerative diseases of the musculoskeletal system.

- In vivo study of spinal fusion on large animals (pigs) using stem cells, growth factors and special designed biodegradable FDM made PCL-TCP biocages - Bone Tissue Engineering, Biomaterial design using electrospinning (Collagen (I and II), PCL and HYAFF nanofibers) and FDM techniques (PCL-TCP)

- Instructed and supervised lab personal and medical undergraduate/graduate students studying for a doctorate - Tissue Engineering of cartilage with human mesenchymal stem cells (MSC) - Mechanobiological influences on human stem cell differentiation - Angiogenesis research - Patent defense

Relevant Coursework: e.g. • Pharmaceutical Chemistry • Pharmaceutical Technology • Pharmaceutical Biology • Pharmacology, Microbiology, Instrumental Analysis, Physics