Dr. Dhananjay Suresh

I am currently developing nanotechnology platforms that involve (i) designing multi-targeted Nanotherapeutics using gold or polymeric substrates to target tumors for selective delivery of siRNA and chemodrugs, and (ii) designing nanosensors for smart, sensitive and accurate diagnostic kits. The technologies are being applied towards Lung, Breast and Ovarian Cancer therapies.

Post-doctoral research involved (i) combating drug-resistance by knocking out oncogenes using siRNA-based nanotherapeutics or CRISPR gene editing, and (ii) studying the gut microbiome and neuronal behavior in animals exposed to nanoparticles.

Developed RNAi nanocarriers

My doctoral studies focused on physical and biological nanoscale interactions of cubic nanomaterials with ultrafast light and cellular organisms. I studied how receptor-targeted nanoparticles (i) interacted and endocytosed in cancer cells and (ii) can be applied towards CTC detection and biomarker characterization. I investigated nanofocusing phenomena in cubic nanomaterials. Finally, I studied the pro-metastatic AXL genetic pathway in Non-small cell Lung Cancer (NSCLC) to develop gene therapy.

PHY 4190/7190; BIOLEN 4480/7480 I formulated course-plan, exam questionnaires and instructed laboratory modules. Each class was focused on a specific nanochemistry topics aimed at practically synthesizing and analyzing nanomaterials.

I studied research methods pertaining to development and application of Nanopore membrane sensors at the Gu-Nanobiotech Lab.

I studied bionanomechanical properties of flagellar constructs pertaining to cellular F1 ATPase rotary motors using Atomic force microscopy. Additionally, I developed thin films (<10 nm) using Langmuir Blodgett and performed Contact-mode Force Adhesion studies.

Led an experimental study to investigate the growth kinetics of proprietary recombinant e.coli strain using pilot-plant bioreactors and biochromatographic processing techniques. The results of the study formed my Thesis titled “Study of Growth Kinetics and Processing techniques Involved in Fermentation of Recombinant E.Coli Strain”.

Field Of Study Nanosensor commercialization | In this biodesign program, I prepared and pitched a business plan and strategy for commercializing a glucose biosensor and TKI-pharmaceutical.

Dissertation titled "Cubic and Spherical Nanoparticles for Detection and Therapy of Cancer"

Dissertation titled “AFM Study of Axonemal Microtubules and Flagellar surface structure isolated from Chlamydomonas Reinhardtii”