John Tholen

Provide technical expertise in regard to purification/filtration systems and products for laboratory and manufacturing operations across a broad industry group (Food and Beverages, Chemical, Medical, Pharmaceutical). Facilitate business alliances, attend trade shows and support sales and marketing operations

Provided strategic direction, tactical oversight and technical expertise for establishing international life science business developments.

1. Provide strategic planning and operational management involving international market research and detailed due diligence reports in support of company/product development opportunities. 2. Established the ‘Centre for Biomedical sciences and Management’ with ful P&L responsibility from start-up to SGD20M per annum. 3. Developed corporate strategy and product positioning; services and product specifications, launch plans, and strategic marketing materials

1. Conducted international clinical diagnostic market research 2. Created and implemented a strategic intellectual property program which evaluated current IP assets and produced strategies for the creation of new, high-value IP. 3. Facilitated international business alliances and joint funding (EU1million EUREKA grant) 4. R&D immunodiagnostic test strips for colon cancer; pregnancy; Candida; and Hepatitis B. 5. Developed manufacturing technology for high throughput production of test strips

1. Managed clinical diagnostic operations for renal hypertension, immunology and endocrinology laboratories. 2. Managed pre-clinical/clinical research projects

Investigated bile acid metabolism and the incidence of bile duct stenosis and liver cirrhosis in cystic fibrosis patients.

1. Development of clinical diagnostics for coronary arterial disease. 2. Investigated toxic alkaloids in agricultural products and developed diagnostics for use in biotechnology. 3. Conducted research on bio-catalysis in organic synthesis

1. R&D formulation of complex catalysts for use in production of exhaust catalytic converters including transfer to pilot production 2. Managed the GMP production of specialty chemicals. 3. Conducted NATA testing of precious metals in mine samples, jewelry items, electronic components, etc.

Nucleic acid metabolism and antihypertensive drug mechanisms

Natural products (Alkaloids) investigation and development of diagnostics instrumentation for application in agricultural biotechnology