Dr. Junhua Qiao

PhD scientist with proven scientific tracking on molecule biology, cell culture and process development, gene regulation and gene targeting, cell line development (CHO), process development, tech transfer, CMC project management and business development; Broad knowledge of therapeutic protein development: from drug discovery, process development, cGMP manufacturing to US/China IND filing; Profound CMC project management skills: including budget, timeline, deliverable, communication and risk management;

Cell culture II Group Process Science Germany Trouble-shot and optimized a targeted-integration based cell line development project, Led a collaboration project with an academic institute to develop a high through-put screening method to identify high expression loci in CHO genome

Institute of Biotechnology / Laboratory of Molecular Biotechnology EPFL/UNIL Developed transgenic cell lines in mammalian cells to investigate the functions of regulatory genomic elements on transgene expression Collaborated with an HHMI lab to visualize gene transcription on single molecule level in live cells Supervised master and PhD students

Coordinated a cell line development project with industrial partner (InVivo Biotech Services, Berlin); routinely reported to CSO of InVivo, oral and written; Developed a novel method to generate cell lines with stable and predictable transgene-expression properties in a timeline-efficient, cost-effective and high-throughput manner; Supervised Master student for practical courses and thesis researches; Embedded in other project teams, providing scientific advices and/or technical supports;

Internship in Polymer Research Department in BASF Ludwigshafen, Germany; Project: Synthesis and Characterization of New Superplasticizers with Anticorrosion Monomers; Working Group: Dr. Stefan Becker

Rotation training within different sub-companies of Carrier China Corporation; Implemented projects in marketing analysis, dealer management, quality and cost control with other trainees

PhD thesis: “Systematic Study on Generation of Mammalian Production Cell Lines with Targeted Integration (RMCE)”

Master Thesis: “Systematic Generation of Mammalian Production Cell Lines: Characterization and Re-use of Genomic Transgene Integration Sites”