Dr. Lucia Cadetti

Monitoring multicenter phase II-III international clinical trials in compliance with GCP/ICH and SOPs (monitoring visits, supporting clinical staff, Liaising with outsourced Data Management services and sponsor, documenting and notifying deviations from protocol, GCP and SOPs, Data cleaning and data capturing, Developing study tools) Authoring study documentation, including protocols, ICs and source notes Preparing and submitting a Phase III clinical trial to Ethics and regulatory authorities

I am integrating my biophysical skills to the molecular biology expertise of the group where I am working in, to characterize glutamate transporters at the first retinal synapse. To do so I have assembled two electrophysiology set-ups, one for oocyte recordings and one for patch clamp recordings. I have given master students lessons about electrophysiology, sleep, ribbon synapses and brain machine interfaces. I regularly communicate my results at internal and external meetings.

I worked on animal models of retinitis pigmentosa, a pathology where the death of retinal photoreceptors induces blindness. I investigated the properties of the surviving cells, both with biophysical and immunohistochemical techniques and I monitored the protective effects of taurine, a not essential aminoacid, on the retina of the same animal models. I cooperated with physicians and engineers to the development of a retinal prosthesis.

In this position I mastered the patch clamp technique to investigate the complex mechanisms that regulate synaptic transmission; I performed double patch clamp recordings and capacitance measurements. In this challenging and very stimulating environment, I learned how to be well organized, productive and cooperative.