Dr. Magnus Mayer

1. Project management - managing the development of medical devices in a regulated environment from idea to bedside - leading interdisciplinary product development teams - managing collaborations with business partners 2. Research Scientist - identification and evaluation of new targets - planning, supervising, and performing lab work with a focus on protein biochemistry to develop new adsorbers for the TheraSorb apheresis sytem

Continuation of my PhD project with a focus on Fluorescence Live-Cell Imaging techniques.

Studying the binding of metal ions, oligomerization and cell adhesion of the APP protein family both in vitro and in cell culture/primary neurons. Techniques: - Recombinant protein production with Pichia pastoris - Biochemical assays: ELISA, Western-Blot, analytical FPLC - Biophysical techniques: MALDI-MS, Biacore (SPR), CD - Live-Cell Imaging: FRET, confocal microscopy

Division: Molecular organization of the nuclear envelope Supervisor: Dr. Eric Schirmer Project: Centromere position in HL-60 cells and involvement of NET23 in centromere positioning

Division: Synaptic Cell Physiology Supervisor: Dr. Christophe Mulle Project: Interaction of profilin II with kainate receptor subunits

Structure and function of the amyloid precursor protein family.