Dr. Nasrin Haghnazari Sadaghiani

My doctoral research investigated how metabolic stress disrupts cellular quality control mechanisms, with a focus on autophagy regulation in human endothelial cells exposed to glycative stress (glyoxal / advanced glycation end products). Using the AMPK–mTOR signalling axis as a central framework, I characterised a late-stage blockade in autophagic flux and studied differential organelle responses including lysosomal trafficking, ER stress and ER-phagy, and mitochondrial quality control.

Operational coordination of the ProMoAge international PhD research programme, supporting activities across multiple internal departments and external academic partner institutions. Responsibilities included managing deadlines and deliverables, preparing regulatory-compliant documentation for the DFG funding body, organising scientific workshops and programme meetings, and serving as the primary communication interface between researchers, programme leadership, and external partners.