Dr. Nicolas P. F. Barthes

- Design & synthesis of heteroaromatic tridentate iron-chelators to address the KDM4A Demethylase; - Hit-to-Lead optimization of inhibitors of the novel KMT9 lysine methyltransferase; - Preparation of cyanine dyes as chemical probes for SNAP- and Halo-tag protein labeling to assess homodimerization of Opioid receptors; - Synthesis of a focused library of ε-alkylated lysine derivatives to target epigenetic enzymes. - Interns and Ph.D. students supervision - Group Leader: Prof. Dr. Manfred Jung

Development of new ratiometric fluorescent probes and incorporation into DNA oligonucleotides to study nucleic acid / protein interactions (HIV, DNA repair and DNA methylation) and DNA conformational changes Group Leader: Prof. Dr. Alain Burger Project Advisor: Dr. Benoit Michel

Synthesis and characterization of new fluorescent probes and incorporation into DNA oligonucleotides to study DNA methylation mechanism involving UHRF1 and DNMT1 Group Leader: Prof. Dr. Alain Burger Project Advisor: Dr. Benoit Michel FRM Grant (Fondation pour la Recherche Médicale) Thesis Link: https://hal-unice.archives-ouvertes.fr/tel-01430507/

Total synthesis of Koningic acid, a natural sesquiterpene exhibiting potential anti-cancer activity by selectively and irreversibly inhibiting GAPDH Group Leader: Dr. Rachid Benhida Project Advisor: Dr. Benoit Michel

Development of synthetic methods, using 2-Chloro-1,3-dimethylimidazolinium chloride as activating agent, to access two series of cinnamic-based antimycobacterial drugs Group Leader: Dr. Stefan Chassaing

Synthesis of new anti-fungal derivatives exhibiting high activity against Phytophthora Group Leader: Dr. Jacky Vidal Project Advisor: Mr. Gerard O'Neill

Solid Phase Peptide Synthesis (SPPS) of therapeutic cyclodepsipeptides Group Leader: Dr. Alain Pellet Project Advisor: Mr. Michel Geslin