Dr. Nicolas P. F. Barthes
Fähigkeiten und Kenntnisse
Werdegang
Berufserfahrung von Nicolas P. F. Barthes
- Current 3 years and 7 months, since Nov 2022Randstad (Schweiz) AG
Consultant Professionals Life Sciences
- 2 years and 1 month, Oct 2020 - Oct 2022
Research Chemist
SpiroChem
- 4 years and 1 month, Sep 2016 - Sep 2020Albert-Ludwigs-Universität Freiburg
Post-Doctoral Researcher in Drug Discovery Chemistry
- Design & synthesis of heteroaromatic tridentate iron-chelators to address the KDM4A Demethylase; - Hit-to-Lead optimization of inhibitors of the novel KMT9 lysine methyltransferase; - Preparation of cyanine dyes as chemical probes for SNAP- and Halo-tag protein labeling to assess homodimerization of Opioid receptors; - Synthesis of a focused library of ε-alkylated lysine derivatives to target epigenetic enzymes. - Interns and Ph.D. students supervision - Group Leader: Prof. Dr. Manfred Jung
- 1 year, Sep 2015 - Aug 2016
Post-Doctoral Researcher in Organic Chemistry
Université Nice Sophia Antipolis (membre d'Université Côte d'Azur)
Development of new ratiometric fluorescent probes and incorporation into DNA oligonucleotides to study nucleic acid / protein interactions (HIV, DNA repair and DNA methylation) and DNA conformational changes Group Leader: Prof. Dr. Alain Burger Project Advisor: Dr. Benoit Michel
- 3 years and 3 months, Oct 2012 - Dec 2015
Ph.D Student in Organic Chemistry
Université Nice Sophia Antipolis (membre d'Université Côte d'Azur)
Synthesis and characterization of new fluorescent probes and incorporation into DNA oligonucleotides to study DNA methylation mechanism involving UHRF1 and DNMT1 Group Leader: Prof. Dr. Alain Burger Project Advisor: Dr. Benoit Michel FRM Grant (Fondation pour la Recherche Médicale) Thesis Link: https://hal-unice.archives-ouvertes.fr/tel-01430507/
- 6 months, Jan 2012 - Jun 2012
M.Sc. Intern in Drug Discovery Chemistry (10th semester)
Université Nice Sophia Antipolis (membre d'Université Côte d'Azur)
Total synthesis of Koningic acid, a natural sesquiterpene exhibiting potential anti-cancer activity by selectively and irreversibly inhibiting GAPDH Group Leader: Dr. Rachid Benhida Project Advisor: Dr. Benoit Michel
- 2 months, May 2011 - Jun 2011
M.Sc. Intern in Drug Discovery Chemistry (8th semester)
ITAV - Institut des Technologies Avancées en sciences du Vivant
Development of synthetic methods, using 2-Chloro-1,3-dimethylimidazolinium chloride as activating agent, to access two series of cinnamic-based antimycobacterial drugs Group Leader: Dr. Stefan Chassaing
- 1 year, Sep 2009 - Aug 2010
B.Sc. Apprentice in Drug Discovery Chemistry
Bayer CropScience AG
Synthesis of new anti-fungal derivatives exhibiting high activity against Phytophthora Group Leader: Dr. Jacky Vidal Project Advisor: Mr. Gerard O'Neill
Solid Phase Peptide Synthesis (SPPS) of therapeutic cyclodepsipeptides Group Leader: Dr. Alain Pellet Project Advisor: Mr. Michel Geslin
Ausbildung von Nicolas P. F. Barthes
- 3 years and 3 months, Oct 2012 - Dec 2015
Organic chemistry
Université de Nice Sophia-Antipolis
- 10 months, Sep 2011 - Jun 2012
Chemistry in Health
Université Paul Sabatier (Toulouse III)
- 10 months, Sep 2010 - Jun 2011
Organic chemistry and biological chemistry
Université Paul Sabatier (Toulouse III)
- 1 year, Sep 2009 - Aug 2010
Organic and bioorganic chemistry
Université Paris-Sud
- 1 year and 10 months, Sep 2007 - Jun 2009
Chemistry
Université Paul Sabatier (Toulouse III)
Sprachen
French
C2 (Verhandlungssicher / Muttersprachlich)
English
C1 (Fließend)
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