Rainer Knoll

PhD Student in the working group of Prof. Joachim Schultze (DZNE & University Bonn) in the field of bioinformatics. Main topic: Multi-omic data analysis for the 2000 HIV Human Functional Genomics Partnership Program, a large clinical study with 2000 participants to uncover novel mechanisms and drug targets in chronic HIV infection. This clinical study is carried out in collaboration with the Radboud University (Prof. Mihai Netea group) and financed by ViiV Healthcare.

Master Thesis in the lab of Prof. Joachim Schultze (Bioinformatics) under the supervision of Dr. Thomas Ulas. Topic is the analysis of clinical single-cell RNA Sequencing data using R of HIV infected but treated patients to discover novel reasons for chronic diseases related to HIV infection. This analysis is the pilot project for the 2000 HIV Human Functional Genomics Partnership Program (HFGP-2000HIV) in collaboration with the Radboud University in Nijmegen.

Student Assistant for Prof. Gütgegmann (Institute for Pathology) in collaboration with Prof. Andrew Gentles (Standford). Statistical Meta Analysis of pediatric tumor entities using PRECOG and Cibersort, comparison to adult tumors.

Student assistant in the Institute of Pathology working in the secretariat. Database entry of tumor pathological findings.

Research Intern at the Lead Discovery (Biochemistry) Department under the supervision of Dr. Andreas Timmermann. Development of biochemial and cellbiological assays. Investigation of RNA-targeting small molecules and GPCRs in cell culture.

Student assistant for collection and uploading of single-cell RNA Seq. datasets for the platform FASTGenomics powered by Comma Soft AG in cooperation with the Limes-Institue (University Bonn).

Master Student Internship in the Lab of Prof. Schultze (Bioinfromatics). Analysis of clinical bulk RNA-Sequencing from chronic obstructive pulmonary disease (COPD) patients and single-cell RNA-Sequencing data of patients with Alzheimer's disease. Additionaly establishment of the Shiny-Seq App using R Shiny. See publication: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4471-1

Master Student Internship in the Lab of Prof. Thiele. Tracing of "click" labeled lipids by using Mass Spectrometry (ESI-MS) for analysis (Lipidomics). Method is described here: https://www.nature.com/articles/s41592-019-0593-6

Bachelor Thesis in the lab of Prof. Schweizer (Selenoproteins, Thyroid Hormones, tRNA) at the IBMB. Topic of the Bachelor Thesis: Establishment of a RT-PCR method to estimate the base modification of adenosne 37 in tRNAs. The thesis was written in English and supervised by Dr. Fradejas-Villar.

Student assistant position. Tutor for Biochemistry (advanced) for students from the Bachelor Molecular Biomedicine. Teaching and assisting students to understand advanced theories and reactions in biochemistry.

Student assistant position. Tutor for Biochemistry (beginners) for students from the Bachelor Molecular Biomedicine. Teaching and assisting students to understand the main theories and reactions in biochemistry.

Student assistant position. Tutor for Organic Chemistry for students from the Bachelor Molecular Biomedicine. Teaching and assisting students to understand the main theories and reactions in organic chemistry.

Biochemie Bioinformatik Medizinische Chemie

Biochemie Immunologie Medizinische Chemie