Prof. Dr. Sina Oppermann

Research focus on functional precision medicine in the field of hematology/oncology: 1) pharmacological image-based and metabolic drug response testing on 2D and 3D primary tumor cultures derived from high risk cancer patients 2) establishment of predictive disease models 3) discovery of drug resistance mechanisms caused by the tumor microenvironment 4) bioinformatical drug scoring analysis and pharmacological information for tumor boards and clinical translation

Postdoctoral researcher Translational oncology Large-scale drug screening of primary leukemia and lymphoma samples for treatment stratification Translational pharmacology, preclinical 3D image-based and metabolic drug screening of solid pediatric tumors and clinical translation.

Postdoc at Sunnybrook Research Institute, Toronto, ON, Canada. Department of Biological Science and Oncology, Biochemistry/Cell Biology and Clinical Hematology, laboratories of Prof. David W. Andrews and David E. Spaner. Focus on High-content image-based single agent and combination drug screening of primary leukemia samples to overcome drug resistance. Mechanistical studies on Venetoclax (Bcl-2 inhibitor) resistance.

PhD Canidate in clinical pharmacy and pharmacology, field pharmacy at the Philipps-University Marburg, Germany. Studies focused on Stroke and Alzheimer disease, with focus on screening of new chemical molecules to inhibit Bid-mediated apoptotic cell death, crystallography of bcl-2 proteins, studies on protein-protein interaction studies and mediators of oxydative cell death.

6-month Pharmacy internship at Merck Serono Darmstadt, Darmstadt, Germany. Department of Exploratory Development – NBEs, Research position as pharmaceutical trainee (practical year, second half), Supervision by Dr. Uezguen. Project: “Relevant Freez/Thaw stress conditions for antibody preformulation development”

Intern at Mundipharma Research GmbH & Co, Clinical Supplies, Limburg, Germany. Department of Pharmaceutical Development, research internship, Supervision by Dr. Leuner. Project: “Design and control of clinical trials- oxycodone/naloxone for pain treatment”