Dr. Ulrich Abel

Heading a department in charge of in-vitro & in-vivo pharmacology, efficacy models, mode of action studies, CRO management, biocompatibility evaluation, tox testing, ADME, DMPK, and Medical Communication.

Preclinical project lead. In charge of API development including route scouting, process R&D, upscaling, API production under GMPs, process transfer to CDMOs, analytical method development & validation, compound library and database management.

Heading the Chemistry Department including sections for Medicinal Chemistry, Drug Design and Repurposing. Project Leader of a CNS Drug Discovery Project. Conducting Drug Discovery and Development with the goal to generate and optimize leads, select candidates for preclinical development and manage process R&D and analytical development to provide API for clinical trial supply.

Directing Phenex´ Medicinal Chemistry program. Coordination of a global CRO network. Lead optimization of novel nuclear receptors modulator series for FXR and LXR. Process research and development. Coninventor clinical stage FXR Agonist PX-102.

Goup leader and lab head. Chemistry project lead for identification and optimisation of MEK inhibitors, beta-secretase inhibitors and melanocortin-receptor modulators. Coinventor of clinical stage 2 MEK-inhibitor Pimasertib

Set up and integration of bioLeads´ synthesis group focussing on natural product total synthesis, semi-synthesis and parallel synthesis. Development of the Diversity Modified Natural Scaffolds concept DYMONS for the generation of semisynthetic natural product-derived compound libraries. Semisynthesis of Fredericamycin derivatives.

Postoc with Prof. Paul Bartlett. Design and solid phase synthesis of peptidomimetic beta-sheet breakers (@-tides). Studies on dimerization kinetics and structural characterisation of @-tides by NMR. Postdoctoral Fellow of the Deutsche Forschungsgemeinschaft DFG.

Postoc at Prof. Isvan E. Markó´s group. Natural product synthesis. Studies towards the Total Synthesis of milbemycin beta-3 emplyoing the intamolecular silyl-modified Hosomi-Sakurai reaction. Methodological studies on allylsilane chemistry.

Diploma thesis at Prof. Martin E. Maier´s group: synthesis of a novel Dynemicine-A analog. PhD thesis at Prof. Dieter Schinzer´s group: Asymmetric Synthesis and Diastereoselective Alkylation of Planar Chiral Tricarbonyl(h6-2-tetralone-oxime)chromium(0) Complexes