Wenbo Ma

Postdoctoral Researcher | Multidisciplinary Disease Mechanisms Conduct cutting-edge biomedical research at the intersection of cardiovascular biology, immunology, and computational genomics within the Max Planck Institute for Heart and Lung Research. Establish and cellularly profile models to dissect disease pathology, mapping pathways that link tissue-level dysfunction with systemic immune and neural responses (neuro-immune axis).

LMU University Hospital, Department of Psychiatry and Psychotherapy, Project: Investigating TAOK2 as a signaling integrator governing synaptic plasticity and neuronal connectivity • Neuronal Dynamics & Imaging: Designed and executed live-cell calcium imaging experiments to characterize ERK-Calcium dynamics in primary neurons, revealing defects in synaptic signaling trajectories. • Data Analysis Pipeline: Developed reproducible Python/R-based workflows to process complex time-series imaging data, correlatin

Project: Mechanism research on gut motility disorders, microbiota regulation, and increased risk of Inflammatory Bowel Disease (IBD) •Processed RNA/DNA sequencing data to study microbiota dysbiosis and inflammatory signaling. •Contributed to QC, normalization, and microbial community analysis using R and command-line tools.

Project: A pattern of lncRNAs for gene regulation in induced pluripotent stem cells from patients with Down syndrome determined by integrative analysis of lncRNA and mRNA profiling data • iPSC Disease Modeling: Established and maintained human iPSC-derived models from patients with Down Syndrome to investigate neurodevelopmental abnormalities. • Mechanism Study: Integrated DNA methylation and transcriptomic profiling to elucidate gene-regulatory mechanisms in patient-derived cells. • Assay Development: Opti

Project: Characterization and Catalytic Properties of RecE Truncation Variant. • Designed and led the project, performed protein expression, purification, and catalytic activity assays.

Project: Preparation of Active Peptides from Giant Salamander and Their Effect on BV-2 Microglial Neuroinflammation. • Investigated the effects of natural bioactive peptides on neuroinflammatory responses.