Dr. David Palesch

Entwicklung von Immuntherapien

As an experienced leader of a cross-functional team, I drive the development, establishment and routine application of cell culture-based, immunological, and virological methods to facilitate the clinical development of cancer immunotherapy. Prior to this, I have successfully led projects in Germany and the USA which investigated new therapeutic approaches in various fields of immunology, virology, and gene therapy in vitro as well as in vivo.

Project leader Projects: Comparative genomics of host immunity in primates to identify new biomarkers and drug targets (published in Nature); Immunotherapy study in rhesus macaques; CD8+ T cell-mediated virus suppression;

Projects: HIV latency establishment and reactivation in primary T cells; Development of natural and synthetic enhancers of lentiviral gene transfer

Projects: Generation and characterization of AAV vectors for combination immunotherapy against HIV-1, XMRV pathogenesis, Enhancers of retroviral/lentiviral-mediated genetherapy,

Project: Characterization and regulation of cathepsin expression in primary antigen presenting cells and its functional role in autoantigen processing

Projects: Antigen processing and presentation

Projects: Functional analysis of GAD65-derived protease-resistant peptides using peripheral blood cells from patients with type 1 diabetes mellitus

T cell immunology, HIV virology, viral vectors, AAV, gene therapy,

Immunology, T cell response, antigen presentation