Del Freeberg

Principal investigator for all natural products-based feed supplements. Chief process design scientist. Process development and product formulation, materials specification and qualification, analytical method development, and trace component analysis. Process development from biological matrices through finished product, including extraction, purification design, and final formulation.

Purification process design from fermentation and biological matrices. Final authority for all technical activities and initiatives. Bid and proposal writing responsibility. Contract evaluation, negotiation, and execution.

Technical project leader. Principal-level scientific and cGMP regulatory responsibility for analytical method development, validation, and implementation. Chief separations and HPLC consultant to the company. Teaching responsibilities in development methodologies and chromatography. No 483s: Principal contributor to the scientific team evaluated by the FDA in a Pre-Approval Inspection in December, 2005. First instance of an inspection without 483 citation in the 26-year history of the company.

Chief separations scientist at the facility. Technical signing authority for all matters pertaining to chromatography, new leads analytical qualification, analytical and preparative HPLC, and sample preparation. Innovation: Created efficient isolation processes from broths. Examples: Delivered five gram lots of cyclosporin and doxorubicin analogues with 80-86% recovery in two-step processes.

Natural products purification process development expertise. Scale-up in pharmaceuticals and nutraceuticals. Project management and supervisory responsibilities. Process Design: Chief inventor of four steps of the 3rd generation paclitaxel process. Coordinated research and development of all four steps to pilot and production. Recovery increased 80% over 2nd generation process. Rework reduced by 85%. Process cost reduced by 42%. Savings of several million dollars over 2nd generation process.

Peroxide chemistry