Dr. Irmgard Hofmann

Leading a research laboratory in cancer biotherapeutics discovery; Identification and validation of oncology drug targets using various approaches such as RNAi; Development of novel therapeutic concepts including literature searches to identify targets of interest with consideration of medicine and marketing aspects, development of validation plans followed by experimental validation

Responsible for a laboratory of 6 technicians including hiring of staff; Development and implementation of binding assays and functional cellular assays using various formats; Bioanalytical representative in multidisciplinary teams for internal pipeline projects; Bioanalytical expert in several collaborations with external partners; Responsible for collaboration project involving several departments

Research on the RAS and PI3 kinase signalling pathways in vitro and in vivo; Drug target validation using shRNA technologies in vitro and in vivo; Xenograft studies to investigate efficacy and PK/PD profiles of compounds; Supervision of 2 master projects of final year pharmacy / biology student; Part of internal collaboration to decipher mechanism of action of compound

cloning; DNA digest; gel electrophoresis

Tumorbiologie; Immunologie; Virologie; Molekularbiologie

Membrane trafficking; Fluorescence microscopy and live cell imaging; Cell culture; Transfection; Immunofluorescence