Max Geerlings

Leitung der Produktion und Entwicklung Roche - mtm laboratories AG

Master thesis at Institute of Pharmaceutical Sciences - Department of Pharmaceutical Technology and Biopharmacy: Optimization of siRNA nanocomplexes for the therapeutic knock-down of Smad6 in the BMP signaling pathway. Mehr im Detail: Entwicklung und Optimierung von Dendriplexen und Lipoplexen als Kandidaten einer Nanoformulierung zur Herunterregulierung von Smad6 im BMP (bone morphogenetic proteins)- Signalweg mittels Antisense-Gentherapie bei kardiovaskulären Erkrankungen.

Particle lab and analytical process optimization: -GMP-compliant implementation and documentation of analyzes with sample materials from sterile drug product manufacturing. -Processing AQL and QC patterns, as well as default patterns, complaints and special investigations. -IT support in computerized system validation (CSV) and device (re)qualification. -Exchange with the interfaces. -Accompanying service technicians to carry out maintenance work in the GMP area. -Supervision of student interns.

Project in the scope of Lean Production/Development: Proof-of-concept study for a new workflow to develop market formulations using roller compaction dry granulation. Advanced Training: Six Sigma / Lean Management White Belt - Zertifikat (Lean Six Sigma, VSM, SIPOC, DMAIC)

Project to develop new monomers for high-performance resins: Organic synthesis and analysis of new monomers, e.g. Bismaleimides, for the production of high-performance resins and pharmaceutical polymers.

-Solid-phase peptide synthesis, HPLC/MALDI-TOF-MS analysis and preparation of various PSMA (prostate-specific membrane antigen) ligand structures. -Determination of internalization rates and receptor-ligand affinities of various PSMA ligands on human cancer cell lines by means of radioassays. Bachelor thesis: Synthesis for preclinical evaluation of F-19-labeled PSMA inhibitors with varying linker structure

Tasks at production, quality control, laboratory, filling, logistics and partner companies.

Master of Science Pharmazeutische Wissenschaften + 1 Jahr freiwillige Berufstätigkeit/Praktika in der pharmazeutischen Industrie (Hoffmann-La Roche) in Basel (Schweiz) und Mannheim

Bachelor of Science Biotechnologie (Bioengineering engineer)

Allgemeine Hochschulreife / Abitur