Dr. Aksana Labokha

•Financial models (rNPV and cash flow) for two projects in Infectious Diseases •Performed market gap analysis to build up portfolio for Infectious Disease Unit •Attended BIO Europe 2018, led and participated in multiple partnering meetings •Assessed the list of attendees and arranged meetings with relevant potential partners at BIO Europe 2018 •Market landscape assessment for AD to utilise deal precedence in negotiations at J.P. Morgan Healthcare Conference

o Lead protein purification team and manage work of three direct reports, liaise with functional groups and project leaders o Perform purification and QC analysis of lead drug candidates (monoclonal antibodies, antibody conjugates) and antigens to support on-going projects o Work on DSP process development to allow parallel activities pre-transfer to CMO that shorten timelines from DC to IND

o Led protein purification team and managed work of three direct reports, liaised with functional groups and project leaders o Succefully managed Immuno-oncology project o Performed purification and QC analysis of lead drug candidates (monoclonal antibodies, antibody conjugates) and antigens to support on-going projects o Coordinated shipment of material to CROs for pre-clinical studies

Primary research project: "Modularity of immunotoxins for efficient intracellular delivery" Project in collaboration: "Validation of drug candidates targeting oncogenic signaling pathways" • Initiated collaboration with the University of Bath to work on a photodynamic therapy approach • Took active part in brainstorming sessions on how to boost innovation at MedImmune

I tutored GCSE (Science), AS- and A-level (Biology and Chemistry), as well as PhD students at the University of Cambridge.

The project was focused on studying novel Trp 3 isoforms as new potential targets for antiretroviral therapy. Skills and experience gained in this position: isolation, growth, maintenance and sorting of primary and recombinant cell-lines, preparation of lentiviral particles. I have supervised research project in collaboration with London Centre for Nanotechnology that resulted in publication in Nature Nanotechnology. I have also supervised student’s project and taught tutorials for MSc Virology at UCL.

Research project: “Impact of O-glycosylation on the permeability barrier of the nuclear pores”. • Experience in protein chemistry (proteomics/mass spectrometry) and biophysics • Developed and implemented mass spectrometry based method to identify O-glycosylation sites • Supervised two research projects in collaboration with NMR group at Utrecht University (The Netherlands) and biophysicists at CIC biomaGUNE (Spain).

PhD thesis: “Functional principles of the permeability barrier that guards vertebrate nuclear pore complexes”. Skills and experience gained: molecular and cell biology, biochemistry, antibody production, developed and scaled-up in vitro O-glycosylation reaction, binding and enzyme activity assays, protein in vitro translation, confocal microscope and cryo-EM.

Life Science, Biochemistry