Ecem Sakallı

Applied advanced genomics workflows (single-cell RNA sequencing, multiomics integration, bioinformatics analysis) to investigate genetics-driven mechanisms of cardiac inflammation and repair, strengthening my understanding of complex genetics laboratory processes. Advised consortium partners on study design, sample preparation, and data interpretation, helping them scope feasible projects and maximise the value of their data.

Ensured high‑quality diagnostic services by maintaining EN ISO 15189 compliance and driving continuous, KPI‑based process improvement, contributing to reduced error rates and more stable turnaround times across the network. Led systematic troubleshooting using CAPA tools to resolve quality issues and optimize lab processes, coordinating between technical staff, clinicians, and management. Led cross-functional team meetings to communicate audit findings, root cause analyses, and improvement plans.

Ensured regulatory compliance and product quality for allogeneic stem cell therapies in a GMP‑regulated facility, collaborating with clinicians and study coordinators. Performed and documented deviations, managed change controls and supported CAPA implementation to address quality events in manufacturing and clinical application. Conducted internal audits of the GMP facility to verify compliance with regulatory standards; summarised findings for regulatory submissions and internal management decisions.

Stem Cell Biology & Molecular Analysis at Genetics Department Investigated embryonic development with complex 2D and 3D cell culture models of stem cells.

Conducted quality control analysis for cellular and tissue products intended for clinical research applications in GMP environment.

Advanced research in tissue engineering and biomaterial characterization with a clinical translation focus.

Thesis: Sex-specific differences in inflammatory and fibroblast responses to myocardial infarction.