Matthias Hufnagel

- Manage nonclinical activities supporting the development of OTC medicinal products and medical devices in a regulated R&D environment. - Drive evidence-generation activities for established products, resulting in scientific publications and posters. - Design, monitor, and interpret preclinical studies to support safety evaluation and development decision making - Provide risk assessments for impurities, extractables and leachables, and product-related safety questions

- Conducted toxicological safety assessments for chemicals and mixtures, including hazard identification, exposure-based risk assessment, and risk characterization - Developed testing and assessment strategies using experimental, literature-based, and alternative method approaches - Applied in silico, in chemico, and in vitro concepts to support regulatory and development-related toxicology questions - Provided toxicological input to innovation projects and portfolio management in an internationally regulat

Current research: Identification of toxicity profiles of granular and fibrous nanomaterials in inhalation relevant mono- and co-cultures after submerged and air-liquid interface exposure (https://nanopartikel.info/en/projects/current-projects/metalsafety-en) www.lmctox.iab.kit.edu

Thesis: Elucidating the toxicity of nanoparticle-containing aerosols after air-liquid interface exposure

Diplomathesis: Flow cytometrix protein quantification using bead-based immunoassay