Frederic Chevessier

Lead discovery and preclinical development of mRNA-based therapeutics, with focus on "rare" disorders including neuromuscular disorders- liver & ophthalmic diseases, now focused on immunology. Oversee cross-functional teams spanning protein design, mRNA engineering, LNP formulation, and in-vivo Proof of Principles Drive program strategy from target selection through preclinical proof-of-concept and IND-enabling activities Ensure regulatory-ready data packages (IND) and alignment with GxP and eQMS standards

Advanced mRNA therapeutic candidates through preclinical evaluation, including in vitro and in vivo models Designed and interpreted Protein-replacement Therapy-Gene Therapy- Immunogenicity studies Contributed to translational strategy and candidate selection Coordinated cross-functional activities across formulation, analytics, R&D, CMC Supported regulatory documentation and scientific reporting for development programs

Developed and implemented novel assays and platforms for mRNA expression and characterization Multiple Proof of principles studies on the use of RNA Therapeutics in different pathologies. Established in vitro and cell-based systems to support candidate screening and selection Contributed to technology development for LNP-based delivery systems

Led research programs on protein aggregation diseases (muscle and neurodegenerative diseases) Designed and executed mechanistic studies in cellular and animal models Supervised students and junior researchers Published scientific findings and contributed to grant applications

Investigated neuromuscular disorders, including congenital myasthenic syndromes (AChR-MuSK) Generated and characterized animal models using embryonic stem cells and homologous recombination Studied neuromuscular junction biology and disease mechanisms

Focus on congenital myasthenic syndromes and congenital muscle diseases Conducted patient stratification and gene identification studies in different neuromuscular diseases (Musk-Agrin-Calsequestrin-STIM-ORA) Developed primary and co-culture systems (nerve–muscle models)

Specialized training in molecular biology and oncology Research project on leiomyosarcoma (Cochin Hospital, Paris)