Dr. Henry Darko

1. Redesigned bioanalytical assays to characterize metabolism small molecule inhibitors and protein degraders in oncology drug discovery. 2. Investigated barriers to oral bioavailability and developed predictive models to bridge in-vitro assays with in-vivo results. 3. Utilized subcellular fractions and whole cells as in-vitro predictive tools to gain a comprehensive understanding of drug release mechanisms. 4. Led the LC-MS method development and validation of ADME assays for prodrug research.

1. Developed synthetic pathways and chiral separation techniques to obtain enantiopure CNS ligands. 2. Evaluated in-vitro pharmacokinetic and metabolic properties of novel neuroactive drugs using LC-MS.

Developed and scaled up formulations and manufacturing processes for oral solid dosage forms targeting the West African market.

1. Formulated oral healthcare products and transferred processes to pilot manufacturing. 2. Authored and reviewed quality documentation for regulatory compliance, audits, and adherence to GMP practices. 3. Monitored the stability of products and packaging materials to ensure suitability for different climatic zones.

1. Reformulated skincare and cosmetic products incorporating inclusive shade ranges for diverse skin tones. 2. Conducted pilot-scale manufacturing of formulations in compliance with GMP principles for user trials.

1. Investigated the efficacy and compatibility of novel raw materials to be incorporated into effervescent denture care formulations. 2. Performed qualitative and quantitative microscopic analysis of microactive foam bubbles in novel oral care formulations. 3. Managed pre-treatment, handling and compliant disposal of human biological samples used in user trials.

Responsible for prescription filling, patient counseling, drug requisition, stock control, and delivery of high-quality client services.

Enantioselective synthesis and pharmacological characterization of CNS ligands.

Pharmaceutical Analysis, Pharmaceutical Technology, Business Management

Pharmacology, Pharmacognosy, Clinical Pharmacy, Pharmaceutics, Medicinal Chemistry