Mrunal Patil

1. Research & Development Lead: Lead the development of novel molecular diagnostics and investigate the structural activity relationships of a new series of functional macro-molecules as a targeting efflux system of Gram-negative bacteria. 2. Technology Transfer Coordinator: Oversee the transfer of developed diagnostic technology and their corresponding protocols to collaborators, and industrial partners for validation in high-priority bacterial pathogens (Yersinia, Burkholderia, Bacillus). 3. Analytical De

Combating Antimicrobial Resistance and Development of Fluorescence-based efflux pump diagnostics in Gram-positive and Gram-negative bacteria Development of diagnostic molecules for detecting efflux-mediated resistance in bacteria 1. Studying the structural activity relationship of fluorescent phenazinium molecules against efflux mutants in Gram-positive and Gram-negative bacteria. 2. Developing a user-friendly rapid detection protocol using screened fluorescent phenazinium molecules. 3. Validation of devel

Development of diagnostic compound for detection of efflux mediated resistance in gram-positive bacteria

Antimicrobial testing of 5-fluorouracil phosphonium derivatives 1. Antimicrobial screening on Gram-positive and Gram-negative bacteria 2. Analysis of disruption in cell division pattern using TEM 3. Self-assembly characterization by CMC determination, DLS and TEM analysis. Antimicrobial testing of Phenothiazine and phenazine derivatives 4. Antimicrobial screening on Gram-positive and Gram-negative bacteria 5. Antibiofilm testing (MBC and MBIC), motility assays, membrane permeation assays, efflux assa

Synthesis and antibacterial evaluation of ionic liquids derived of triaminophenaziums and their sulphur analogs

1. Synthesized and evaluated the antifungal properties of arginine-based lipids (Arginolipids) against clinical isolates of Candida species. 2. Established synergistic effects between Arginolipids and conventional antifungal drugs such as fluconazole and Amphotericin B to enhance therapeutic outcomes. 3. Elucidated the MOA for the most effective Arginolipid using a Saccharomyces cerevisiae gene deletion library. 4. Confirmed the antifungal mechanism of Arginolipids and their combination with antifungal dru

Strategic Project Management Project Management Principles and Domains Project Definition and Finance Project Schedule and Cost Management Project Quality, Risk, and Uncertainty Management Team and Change Project Management Project Team Work Management: Procurement, Legal aspects of contracting,

1. Synthesis of a lipid-based antifungal carrier for improvising drug delivery for treating invasive candidiasis. 2. Development of synergistic essential oil-miconazole-based oral sprayable gel for oral candidiasis.